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Drug Store News - Generic Coumadin OK’d in Florida

admin — Sat, 03 Jan 2009 12:26:03 +0000

The Florida Board of Pharmacy has removed warfarin sodium, the generic version of Bristol-Myers Squibb’s heart drug Coumadin, from its “negative formulary list.”

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The decision to remove Coumadin ends a two-year legislative battle with Florida lawmakers. The annual sales of wafarin sodium products in Florida alone are estimated to be more than $40 million.
COPYRIGHT 2002 Reproduced with permission of the copyright holder. Further reproduction or distribution is prohibited without permission.
COPYRIGHT 2008 Gale, Cengage Learning

Legal Eagle Eye Newsletter for the Nursing Profession - Coumadin: med started before lab tests back

admin — Mon, 29 Dec 2008 16:16:03 +0000

A nursing home resident’s physician ordered lab tests to determine her suitability for Coumadin, but the nursing staff apparently went ahead with the Coumadin before the labs results came back and were evaluated by the physician. The patient had to be hospitalized after she began spitting up blood and bleeding rectally.

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The patient’s lawsuit in the Superior Court, Riverside County, California settled for $100,000. Incardone v. Ben Bennett Inc., 2008 WL 1847175 (Sup. Ct. Riverside Co., California, March 17, 2008).
COPYRIGHT 2008 Legal Eagle Eye Newsletter for the Nursing Profession
COPYRIGHT 2008 Gale, Cengage Learning

Saturday Evening Post - Diet, drugs may affect Coumadin

admin — Sat, 27 Dec 2008 18:51:05 +0000

Q: I was recently hospitalized because my blood was dangerously thin. I was taking Coumadin as prescribed by my doctor. I would appreciate any information and also want to know if Bufferin or aspirin do thin the blood.
Coumadin (trade name warfarin) “thins” the blood by interfering with its normal clotting processes. This action is important in patients who have a condition that may predispose to the development of blood clots, such as some forms of phlebitis, a heart-rhythm problem called atrial fibrillation, foreign bodies in the bloodstream such as artificial heart valves, and a host of other conditions. In these patients, Coumadin can prevent blood clots from forming, and thus prevent dangerous complications such as strokes. The degree to which Coumadin is affecting clotting is monitored by a blood test called INR (international normalized ratio), generally checked monthly. Changes in the dose of Coumadin, diet, and the action of other drugs that can affect the metabolism of Coumadin can reduce or augment its actions.

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When you say your blood was “dangerously thin,” it sounds like something enhanced the effects of Coumadin and your blood became excessively anticoagulated. Think back to whether you added a new medication, changed doses, altered your diet, or did something else that might have affected the Coumadin. Go over this with your doctor because it is important to prevent excessive anticoagulation from happening again. It sounds like you did not have a permanent complication, but that can happen if your blood gets too thin, and such a bleeding complication needs to be avoided.
[ILLUSTRATION OMITTED]
Aspirin (Bufferin is just a trade name for aspirin) also affects the normal clotting process but by a different mechanism. Aspirin interferes with the ability of platelets to clump together to form clots. Sometimes aspirin and Coumadin are taken together, but that can increase the chance of bleeding.
ABOUT THE EXPERT
Internationally acclaimed cardialogist, distinguished professor, author and inventor Dr. Douglas P. Zipes is an authority on what is called pacing and electrophysialogy (rhythms of the heart).
COPYRIGHT 2008 Saturday Evening Post Society
COPYRIGHT 2008 Gale, Cengage Learning

Pharmacy News - ADRAC bulletin reports glucosamine-warfarin interactions.

admin — Mon, 22 Dec 2008 17:51:02 +0000

Tegan Fleming

GLUCOSAMINE supplements commonly used to treat osteoarthritis may pose a risk to patients taking the anticoagulant warfarin, new reports reveal.

The Therapeutic Goods Administration has received 12 reports suggesting an interaction between glucosamine and warfarin, marketed under the brand names Coumadin, Jantoven, Marevan and Waran, the Adverse Drug Reactions Advisory Committee (ADRAC) reported in its latest bulletin.

ADRAC said the mechanism of the interaction was unknown.

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Most of the cases described changes in the international normalised ratio (INR) …

Read the rest of this article with a Free Trial at HighBeam Research.

Internal Medicine News - Top 10 drugs mentioned by cardiologists in 2004

admin — Fri, 19 Dec 2008 01:51:02 +0000

Top 10 Drugs Mentioned by Cardiologists in 2004

Millions of Mentions*

Aspirin 7.6
Toprol XL 5.8
Lipitor 5.1
Coumadin tabs 4.1
Lasix oral 4.0
Zocor 3.5
Norvasc 3.4
Lisinopril 3.2
Coreg 3.1
Atenolol 3.0

*”Mentions” refers to all samples and drugs prescribed, dispensed, or
recommended.
Note: Based on projected nationwide data from a monthly survey of about
94 cardiologists.
Source: Verispan
KEVIN FOLEY, RESEARCH

Note: Table made from bar graph.

Soothing Pineapples as A Natural Treatments for Gout

admin — Mon, 15 Dec 2008 06:06:02 +0000

Have you ever gotten up at night due to a gout attack? If so, you know how frantic you can be looking around for effective treatments for gout that will bring quick relief.
It is very difficult to get rid of gout quickly, so you need to focus on treatments that you can use BEFORE you have an attack! A great natural treatments for gout solution you can use is to eat pineapples. Below are 3 ways pineapples help to reduce the incidence of you getting an attack.
Pineapples help reduce inflammation
Pineapples reduce inflammation, the leading cause of pain in gout due to an enzyme found in pineapples called bromelain. Bromelain is a one of several very potent natural treatments for gout. It helps reduce inflammation by digesting protein molecules.
You can further help yourself by using bromelain as a supplement. Bromelain is used for quite a few different treatments, and is a blood thinner. So, check with your physician before using, especially if you are on Coumadin (Warfarin) or aspirin. Do not take more than the recommended dose as it can lead to nausea,vomiting, or increased heart rate, but when used in moderate doses it has been tested to show no noticeable side effects.
Pineapples help reduce Uric Acid Levels
They accomplish this by the vitamin C that is found in this delicious fruit. Vitamin C helps liquefy uric acid which enables the kidneys to get rid of the extra amounts of uric acid that you are having trouble eliminating. Vitamin C also assists in keeping purines from metabolizing into uric acid. Pineapples contain sixty percent of your daily recommended allowance for vitamin C.

Pineapples Help You Eliminate Uric Acid
On top of Vitamin C and bromelain, they contain potassium. Pineapples are a key ingredient to effective gout treatments therapy. Potassium turns uric acid into liquids instead of crystals to your renal system can eliminate excess uric acid during urination.
Pineapples do not have an overwhelming amount of potassium, but they do help you with your potassium intake. When using potassium with other treatments for gout, your severity and incidence of gout should decrease over time.
From helping to give you gout pain relief, to reducing your uric acid levels, to helping eliminate uric acid, pineapples make an excellent natural treatments for gout.

Change Ordered to Warfarin Drug Label

admin — Fri, 12 Dec 2008 03:36:04 +0000

Aug. 1, 2007 In a new trend, labels on the clot-fighting drug warfarin
will now warn that people with certain gene variationsmay need lower doses
of the drug.
It’s the first time that the FDA has asked doctors to consider a patient’s
genetic makeup when prescribing a widely used drug, says Larry Lesko, PhD,
director of clinical pharmacology at the FDA.
“Today is a significant event for those who see the day when medicine is
tailored to the genetic makeup of each one of its users,” Lesko said at a
news conference.
“We are continuing to engage in various projects that will further
evaluate the relationship between genetic variability and treatment outcomes in
patients,” FDA Deputy Commissioner and Chief Medical Officer Janet
Woodcock, MD, said at the news conference.
The change in the label for warfarin (originally sold under the brand name
Coumadin) does not require
that patients get genetic tests. But the new label suggests that genetic
testing can help doctors find the correct dosage of the drug.
Each year, about 2 million Americans start taking warfarin to prevent blood
clots, heart attacks, and strokes. It is notoriously difficult to find the
right warfarin dosage for an individual patient. Factors such as age, diet, use
of other medications, and use of vitamins and supplements affect the
dosage.
Because of this, warfarin is the second most common drug (after insulin)
that sends patients to the emergency room.
Researchers have noticed that about a third of patients who start warfarin
need much lower doses than expected. This difference appears to be due to
variations in two genes. One of the genes, VKORC1, affects a patient’s
sensitivity to warfarin. The other gene, CYP2C9, affects how quickly a person
clears warfarin from the body.
The new warfarin label suggests that doctors starting a patient on warfarin
might want to have that patient tested for variations in these genes. Most
major laboratories already offer the test. Lesko says the cost of testing
ranges from $125 to $500; a patient would need to be tested only once.
Patients already taking warfarin probably will not need genetic testing if
they already have found the warfarin dosage that works best for them.

A Review of Laser Prostate Procedures

admin — Sun, 07 Dec 2008 17:56:02 +0000

There are new laser treatments available for sufferers of BHP (Benign Hypertrophic Prostate) and other prostate conditions. They are replacing the “gold standard” TURP and TUNA procedures, and are characterized by much shorter recovery periods and are ideal for patients who might also be on blood thinner medication (Coumadin/Warfarin).

There are two competing laser technologies for prostate treatments - you should understand the differences: the Holmium (YAG) laser, and PVP (KPT) laser (otherwise known as “Green Light”.) The differences between the two are in the wavelength of the lasers used, and the nature of the energy transmitted to the tissues.

PVP LASER (Green Light)

The PVP (KPT) laser has a somewhat long wavelength that penetrates the tissue more deeply - in fact, the energy penetrates more deeply than it ablates (removes). What this means is that tissue that is left behind has been affected by the laser. The result can be a phenomenon known as necrosis of the affected tissue: the remaining tissue dies and may require further treatment of other means to remove, down the line.

This is a potential detrimental side effect. Because of the higher possibility of necrosis, PVP is not recommended for larger prostate conditions. It is considered viable for smaller prostates.

HOLMIUM LASER

The Holmium (YAG) laser has a shorter wavelength and penetrates less deeply than the PVP. Energy from the laser is imparted only to the the tissue that is ablated (removed). As a result, there is no necrosis concern.

In a panel discussion of noted urologists comparing the two technologies for HoLAP procedures[1], the experiences of all came down positively for the Holmium vs. the PVP laser.

HoLEP - ENUCLEATION OF THE PROSTATE

With the Holmium laser, it is now possible to completely remove the prostate with minimal side effects. This is called enucleation. The prostate is completely detached with fine (2-3mm) laser instruments, and passed through a pair of incisions in the bladder. It is then sectioned, and the sections are brought into the bladder through the incisions, where they are broken up into passable bits (the bits are passed through the catheter.)

This is becoming the new “gold standared” treatment, replacing the TURP procedure in many advanced urological centers. Side effects are minimal, and, according to one study[2], sexual function (ability to gain and maintain an erection) may actually increase, depending on the nature of prior dysfunction, if any.

WHERE TO GO?

One consideration is going overseas for treatment. HoLEP is available in at least one group of urolotical hospitals located in India, using exactly the same procedures and equipment as in major US facilities. The procedure can be done for as little as a fifth to a tenth of that in the US.

[1]Urological Times [2]Journal of Andrology

Garlic A Powerful Alternative Medicine

admin — Thu, 04 Dec 2008 11:36:03 +0000

Garlic is better known as a condiment and spice used in cooking. It is very pungent both in smell and taste. For thousands of years garlic also has been used as an alternative medicine for the treatment of various health conditions. Garlic was widely used in past great civilizations such as Egypt, China and India.
Researches into garlic since the 1940’s have shown that it has anti-cancer properties. National Cancer Institute’s recent studies have further confirmed that garlic has the ability to inhibit the formation of tumor cells. Garlic can be used as a preventative for some form of cancer such as colon and stomach cancers.
When garlic is used on a long term basis it helps to balance blood pressure and blood sugar. It is also of benefits in the maintenance of healthy circulation and resistance to infection. Garlic is very often used to treat urinary infections, respiratory infections, acne, sinusitis, ulcers, bronchitis and asthma.
Garlic has the ability to restrain bacteria making it a good antibiotic. It shows a better effect than penicillin. Garlic is very effective against strep, enteritis, staph bacteria, cholera and dysentery.
There are many claims that garlic has the ability to reduce heart problems. Garlic thins the blood very much like aspirin. It reduces blood clots and is taken by many to prevent vascular changes that result in cardiovascular disease.
The ability of garlic to inhibit the absorption of cholesterol makes it excellent for lowering cholesterol level. Most cholesterol lowering drugs have some side effects. However, garlic is well tolerated and does not cause any allergic reactions.
Some studies have shown that garlic kills hookworms and other parasites lodging in the intestinal tract. Many cultures have used garlic for thousands of years to get rid of worms and harmful organisms living inside our bodies.
If you are taking the HIV drug Saquinavir, do not take garlic a it can affect the effectiveness of the medication. Should you be undergoing surgery do not take garlic for at least a week before that day. Because garlic reduces blood clots, in excessive bleeding may result during operation. Use garlic with caution if you are on any blood-thinning drugs like Ticlopidine or Coumadin.
You can take garlic raw or cooked. There are also garlic capsules and tablets available in all health food stores. However, researchers have shown that raw garlic produces the best therapeutic effect if used on a regular basis. Garlic has been proven to be a remarkable alternative medicine in its past history and is still as effective today.

Complete Information on Eisenmenger Syndrome

admin — Sun, 30 Nov 2008 01:26:02 +0000

Eisenmenger syndrome develops in the individuals with expressive defects of heart. People who have Eisenmenger are usually constant with a large hole in the heart. The most current situation in which this occurs when there is a hole (defect) between the two rooms of pumping (ventricles), is called a ventricular septal defect (VSD). The syndrome of Eisenmenger.s progresses result of the effects of hypertension in the lungs. This hypertension, or pulmonary hypertension, occurs because of the congenital defects of heart which cause the flow of blood on the left side of the heart at the good side of the heart (shunt of left on the right).
Eisenmenger syndrome develops while the individuals with defects of heart are the motionless children, but it can occur in adolescence or the young adulthood. Infants supported with a large hole between the ventricles of the heart (ventricular septal defect) or whose arteriosus of ductus is not closed after the birth are with the large risk to develop the syndrome of Eisenmenger. This syndrome affects males and females. Symptoms of the eisenmenger include the brevity of the breath, particularly with the activity, extreme tiredness, the lethargy and fainding, giddiness. The treatment for people with the syndrome of Eisenmenger is aimed ordering symptoms and preventing complications.
Medication is the primary treatment option. Anticoagulants (deluentes of blood) such as aspirin or Coumadin is rarely used. The surgery to repair the defect once the syndrome Eisenmenger has become impossible. The transplant of heart and lung or lung transplantation is options for some people with the syndrome Eisenmenger. The supplemental oxygen can be used during periods of sleep or while reclines. The use of oxygen can progress to continuous use for relief of symptoms. Overexertion and smoking also should be of prostacyclin therapy avoided. Long-term were shown to improve hemodynamics.