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AFP - Scientists find gene link predicts blood thinner impact

admin — Tue, 13 Jan 2009 02:51:04 +0000

WASHINGTON (AFP) — US researchers said Wednesday they have found gene variations which predict how a patient will react to the drug warfarin, widely used to prevent blood clotting and treat heart attack victims.
Researchers found that the gene VKORC1 has a key role in predicting how sensitive a patient will be the blood thinning drug in the first week of using the drug — helping doctors deal with the wide variation in responses to the drug.
Studying nearly 300 patients starting therapy with warfarin, the researchers found that variations in VKORC1 can explain why individual patients need greater or smaller doses of the drug to best benefit from it.

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HealthDay - Blood Thinner Linked to Increased Brain Bleeding

admin — Sun, 11 Jan 2009 23:41:05 +0000

The amount of bleeding in the brain that occurs when a blood vessel bursts and causes a stroke is greater for some people who take the clot-preventing drug warfarin (Coumadin), a new study shows.
It’s not a surprising finding, said Dr. Daniel Woo, an associate professor of neurology at the University of Cincinnati and co-author of the report in the Sept. 30 issue of Neurology, since it’s long been established that the risk of death from such a stroke is greater for people taking warfarin.
But there has been a debate about whether the increased risk is due to an increased volume of blood spewed into the brain. The study of 258 people who had brain hemorrhages appears to settle the issue, Woo said: “We did find a larger volume of hemorrhage in these patients.”

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Small Press Bookwatch - The Coumadin Help Book

admin — Tue, 06 Jan 2009 20:41:04 +0000

The Coumadin (Warfarin) Help Book
Diana M. Schneider
DiaMedica
150 East 61st Street, New York, NY 10065
9780979356421, $14.95, www.diamedicpub.com

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The heart is a vital organ, but there is so much wrong that can go with it. “The Coumadin (Warfarin) Help Book” is a manual for the drug known as Coumadin/Warfarin and its effect on the heart. Covering the uses of the drugs and their potentially nasty side effects as well as possible problems that could come with mixing it with certain foods and beverages, author Diana Schneider has written a comprehensive and thoroughly ‘user friendly’ guide book. If one is deciding if the drug is right for them, “The Coumadin (Warfarin) Help Book” is a good read alongside the advice of a physician.
COPYRIGHT 2008 Midwest Book Review
COPYRIGHT 2008 Gale, Cengage Learning

Drug Store News - Generic Coumadin OK’d in Florida

admin — Sat, 03 Jan 2009 12:26:03 +0000

The Florida Board of Pharmacy has removed warfarin sodium, the generic version of Bristol-Myers Squibb’s heart drug Coumadin, from its “negative formulary list.”

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The decision to remove Coumadin ends a two-year legislative battle with Florida lawmakers. The annual sales of wafarin sodium products in Florida alone are estimated to be more than $40 million.
COPYRIGHT 2002 Reproduced with permission of the copyright holder. Further reproduction or distribution is prohibited without permission.
COPYRIGHT 2008 Gale, Cengage Learning

Legal Eagle Eye Newsletter for the Nursing Profession - Coumadin: med started before lab tests back

admin — Mon, 29 Dec 2008 16:16:03 +0000

A nursing home resident’s physician ordered lab tests to determine her suitability for Coumadin, but the nursing staff apparently went ahead with the Coumadin before the labs results came back and were evaluated by the physician. The patient had to be hospitalized after she began spitting up blood and bleeding rectally.

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The patient’s lawsuit in the Superior Court, Riverside County, California settled for $100,000. Incardone v. Ben Bennett Inc., 2008 WL 1847175 (Sup. Ct. Riverside Co., California, March 17, 2008).
COPYRIGHT 2008 Legal Eagle Eye Newsletter for the Nursing Profession
COPYRIGHT 2008 Gale, Cengage Learning

Saturday Evening Post - Diet, drugs may affect Coumadin

admin — Sat, 27 Dec 2008 18:51:05 +0000

Q: I was recently hospitalized because my blood was dangerously thin. I was taking Coumadin as prescribed by my doctor. I would appreciate any information and also want to know if Bufferin or aspirin do thin the blood.
Coumadin (trade name warfarin) “thins” the blood by interfering with its normal clotting processes. This action is important in patients who have a condition that may predispose to the development of blood clots, such as some forms of phlebitis, a heart-rhythm problem called atrial fibrillation, foreign bodies in the bloodstream such as artificial heart valves, and a host of other conditions. In these patients, Coumadin can prevent blood clots from forming, and thus prevent dangerous complications such as strokes. The degree to which Coumadin is affecting clotting is monitored by a blood test called INR (international normalized ratio), generally checked monthly. Changes in the dose of Coumadin, diet, and the action of other drugs that can affect the metabolism of Coumadin can reduce or augment its actions.

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When you say your blood was “dangerously thin,” it sounds like something enhanced the effects of Coumadin and your blood became excessively anticoagulated. Think back to whether you added a new medication, changed doses, altered your diet, or did something else that might have affected the Coumadin. Go over this with your doctor because it is important to prevent excessive anticoagulation from happening again. It sounds like you did not have a permanent complication, but that can happen if your blood gets too thin, and such a bleeding complication needs to be avoided.
[ILLUSTRATION OMITTED]
Aspirin (Bufferin is just a trade name for aspirin) also affects the normal clotting process but by a different mechanism. Aspirin interferes with the ability of platelets to clump together to form clots. Sometimes aspirin and Coumadin are taken together, but that can increase the chance of bleeding.
ABOUT THE EXPERT
Internationally acclaimed cardialogist, distinguished professor, author and inventor Dr. Douglas P. Zipes is an authority on what is called pacing and electrophysialogy (rhythms of the heart).
COPYRIGHT 2008 Saturday Evening Post Society
COPYRIGHT 2008 Gale, Cengage Learning

Pharmacy News - ADRAC bulletin reports glucosamine-warfarin interactions.

admin — Mon, 22 Dec 2008 17:51:02 +0000

Tegan Fleming

GLUCOSAMINE supplements commonly used to treat osteoarthritis may pose a risk to patients taking the anticoagulant warfarin, new reports reveal.

The Therapeutic Goods Administration has received 12 reports suggesting an interaction between glucosamine and warfarin, marketed under the brand names Coumadin, Jantoven, Marevan and Waran, the Adverse Drug Reactions Advisory Committee (ADRAC) reported in its latest bulletin.

ADRAC said the mechanism of the interaction was unknown.

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Internal Medicine News - Top 10 drugs mentioned by cardiologists in 2004

admin — Fri, 19 Dec 2008 01:51:02 +0000

Top 10 Drugs Mentioned by Cardiologists in 2004

Millions of Mentions*

Aspirin 7.6
Toprol XL 5.8
Lipitor 5.1
Coumadin tabs 4.1
Lasix oral 4.0
Zocor 3.5
Norvasc 3.4
Lisinopril 3.2
Coreg 3.1
Atenolol 3.0

*”Mentions” refers to all samples and drugs prescribed, dispensed, or
recommended.
Note: Based on projected nationwide data from a monthly survey of about
94 cardiologists.
Source: Verispan
KEVIN FOLEY, RESEARCH

Note: Table made from bar graph.

Soothing Pineapples as A Natural Treatments for Gout

admin — Mon, 15 Dec 2008 06:06:02 +0000

Have you ever gotten up at night due to a gout attack? If so, you know how frantic you can be looking around for effective treatments for gout that will bring quick relief.
It is very difficult to get rid of gout quickly, so you need to focus on treatments that you can use BEFORE you have an attack! A great natural treatments for gout solution you can use is to eat pineapples. Below are 3 ways pineapples help to reduce the incidence of you getting an attack.
Pineapples help reduce inflammation
Pineapples reduce inflammation, the leading cause of pain in gout due to an enzyme found in pineapples called bromelain. Bromelain is a one of several very potent natural treatments for gout. It helps reduce inflammation by digesting protein molecules.
You can further help yourself by using bromelain as a supplement. Bromelain is used for quite a few different treatments, and is a blood thinner. So, check with your physician before using, especially if you are on Coumadin (Warfarin) or aspirin. Do not take more than the recommended dose as it can lead to nausea,vomiting, or increased heart rate, but when used in moderate doses it has been tested to show no noticeable side effects.
Pineapples help reduce Uric Acid Levels
They accomplish this by the vitamin C that is found in this delicious fruit. Vitamin C helps liquefy uric acid which enables the kidneys to get rid of the extra amounts of uric acid that you are having trouble eliminating. Vitamin C also assists in keeping purines from metabolizing into uric acid. Pineapples contain sixty percent of your daily recommended allowance for vitamin C.

Pineapples Help You Eliminate Uric Acid
On top of Vitamin C and bromelain, they contain potassium. Pineapples are a key ingredient to effective gout treatments therapy. Potassium turns uric acid into liquids instead of crystals to your renal system can eliminate excess uric acid during urination.
Pineapples do not have an overwhelming amount of potassium, but they do help you with your potassium intake. When using potassium with other treatments for gout, your severity and incidence of gout should decrease over time.
From helping to give you gout pain relief, to reducing your uric acid levels, to helping eliminate uric acid, pineapples make an excellent natural treatments for gout.

Change Ordered to Warfarin Drug Label

admin — Fri, 12 Dec 2008 03:36:04 +0000

Aug. 1, 2007 In a new trend, labels on the clot-fighting drug warfarin
will now warn that people with certain gene variationsmay need lower doses
of the drug.
It’s the first time that the FDA has asked doctors to consider a patient’s
genetic makeup when prescribing a widely used drug, says Larry Lesko, PhD,
director of clinical pharmacology at the FDA.
“Today is a significant event for those who see the day when medicine is
tailored to the genetic makeup of each one of its users,” Lesko said at a
news conference.
“We are continuing to engage in various projects that will further
evaluate the relationship between genetic variability and treatment outcomes in
patients,” FDA Deputy Commissioner and Chief Medical Officer Janet
Woodcock, MD, said at the news conference.
The change in the label for warfarin (originally sold under the brand name
Coumadin) does not require
that patients get genetic tests. But the new label suggests that genetic
testing can help doctors find the correct dosage of the drug.
Each year, about 2 million Americans start taking warfarin to prevent blood
clots, heart attacks, and strokes. It is notoriously difficult to find the
right warfarin dosage for an individual patient. Factors such as age, diet, use
of other medications, and use of vitamins and supplements affect the
dosage.
Because of this, warfarin is the second most common drug (after insulin)
that sends patients to the emergency room.
Researchers have noticed that about a third of patients who start warfarin
need much lower doses than expected. This difference appears to be due to
variations in two genes. One of the genes, VKORC1, affects a patient’s
sensitivity to warfarin. The other gene, CYP2C9, affects how quickly a person
clears warfarin from the body.
The new warfarin label suggests that doctors starting a patient on warfarin
might want to have that patient tested for variations in these genes. Most
major laboratories already offer the test. Lesko says the cost of testing
ranges from $125 to $500; a patient would need to be tested only once.
Patients already taking warfarin probably will not need genetic testing if
they already have found the warfarin dosage that works best for them.