Heart Advisor - Genes provide key to dosing formulas for blood thinner
Getting the right dose of the common stroke-prevention blood thinner warfarin (Coumadin) should become easier thanks to researchers who developed dosing formulas based on variations in two key genes, VKORC1 and CYP2C9. Their study, published in the Sept. 1 issue of the journal Blood, supports the U.S.
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Food and Drug Administration’s decision in August to include the gene information on warfarin labels. Warfarin dosing often involves trial and error because factors, such as interaction with other medications, stress, diet, and travel, affect its activity in the body. Physicians can input patient information on the Web site www.warfarindosing.com and receive dosing recommendations.
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